Hematopoietic Stem Cell Transplantation in Pediatric Oncology: Successes and Challenges
Received Date: Jan 01, 2025 / Published Date: Jan 31, 2025
Abstract
Hematopoietic stem cell transplantation (HSCT) has revolutionized the treatment of high-risk and relapsed pediatric malignancies, offering a potential cure for conditions such as leukemia, lymphoma, and certain solid tumors. Over the years, advancements in donor selection, conditioning regimens, and graft-versus-host disease (GVHD) management have improved survival outcomes and reduced complications. However, challenges remain, including transplant-related toxicities, immune reconstitution delays, and the risk of GVHD. Innovations in haploidentical transplantation, reducedintensity conditioning, and post-transplant immune modulation are shaping the future of HSCT in pediatric oncology. This review discusses the successes, ongoing challenges, and emerging strategies in optimizing HSCT outcomes for children with cancer.
Citation: Lures A (2025) Hematopoietic Stem Cell Transplantation in Pediatric Oncology: Successes and Challenges. J Orthop Oncol 11: 304. Doi: 10.4172/2472-016X.1000304
Copyright: 漏 2025 Lures A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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